Recognition of the 60 kilodalton cysteine-rich outer membrane protein OMP2 by CD4+ T cells from humans infected with Chlamydia trachomatis
نویسندگان
چکیده
منابع مشابه
Human CD8+ T cells recognize the 60-kDa cysteine-rich outer membrane protein from Chlamydia trachomatis.
The intracellular bacterial pathogen Chlamydia is sequestered from the host cell cytoplasm by remaining within an inclusion body during its replication cycle. Nevertheless, CD8(+) T cells recognizing Chlamydia Ags in the context of MHC class I molecules are primed during infection. We have recently described derivation of Chlamydia-specific human CD8(+) T cells by using infected dendritic cells...
متن کاملCloning, Expression and Purification of Truncated Chlamydia Trachomatis Outer Membrane Protein 2 (Omp2) and its Application in an ELISA Assay
Background: Although a simple and direct method does not exist for the detection of chlamydial infections, there are situations in which reliable serological tests, with sensi-tivity related to a specific antigen, could be helpful. Objective: The aim of this study was to clone the first 1100 bp of the C. trachomatis outer membrane protein 2 (omp2) gene in order to prepare a recombinant protein ...
متن کاملThe nucleotide sequence of the 60 kDa cysteine rich outer membrane protein of Chlamydia pneumoniae strain IOL-207.
Members of the species chlamydia are characterised by their obligate intracellular life cycle. The genus comprises three species; Chlamydia trachomatis, Chlamydia psittaci and Chlamydia pneumoniae. C. pneumoniae causes acute respiratory infections in humans. This organism has only recently been shown to warrant its own species classification within the chlamydial genus based on immunological, u...
متن کاملCloning, expression and purification of truncated Chlamydia trachomatis outer membrane protein 2 (omp2) and its application in an ELISA assay.
BACKGROUND Although a simple and direct method does not exist for the detection of chlamydial infections, there are situations in which reliable serological tests, with sensitivity related to a specific antigen, could be helpful. OBJECTIVE The aim of this study was to clone the first 1100 bp of the C. trachomatis outer membrane protein 2 (omp2) gene in order to prepare a recombinant protein f...
متن کاملcloning, expression and purification of truncated chlamydia trachomatis outer membrane protein 2 (omp2) and its application in an elisa assay
background: although a simple and direct method does not exist for the detection of chlamydial infections, there are situations in which reliable serological tests, with sensi-tivity related to a specific antigen, could be helpful. objective: the aim of this study was to clone the first 1100 bp of the c. trachomatis outer membrane protein 2 (omp2) gene in order to prepare a recombinant protein ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2001
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2001.01709.x